mTGase (Microbial Transglutaminase) from Yinjia Bio is a highly active recombinant transglutaminase of microbial origin. It features high activity, excellent stability, and high purity. Compared with animal-derived transglutaminases, mTGase has a smaller molecular weight and is calcium-independent. It catalyzes the formation of a stable peptide bond between the glutamine side chain at position 295 of deglycosylated antibodies and a primary amine in the substrate. Since no additional peptide donor is required to drive the conjugation reaction, mTGase is highly flexible and functional as long as a primary amine group is present on the target molecule. For these reasons, mTGase is widely used in the preparation of ADC antibodies.

Product images are for reference only.